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1

Enantioselective Indole Friedel—Crafts Alkylations Catalyzed by Bis(oxazolinyl)pyridine—Scandium(III) Triflate Complexes.

David A. Evans, Karl A. Scheidt, Keith R. Fandrick, Hon Wai Lam, Jimmy Wu

Journal:

Year:

2004

File:

PDF, 201 KB

2004

2

Enantioselective Friedel−Crafts Alkylations of α,β-Unsaturated 2-Acyl Imidazoles Catalyzed by Bis(oxazolinyl)pyridine−Scandium(III) Triflate Complexes

Evans, David A., Fandrick, Keith R., Song, Hyun-Ji

Journal:

Journal of the American Chemical Society

Year:

2005

Language:

english

File:

PDF, 65 KB

english, 2005

3

Assessing Atropisomer Axial Chirality in Drug Discovery and Development

LaPlante, Steven R., D. Fader, Lee, Fandrick, Keith R., Fandrick, Daniel R., Hucke, Oliver, Kemper, Ray, Miller, Stephen P. F., Edwards, Paul J.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 4.54 MB

english, 2011

4

Assay at low ppm level of dimethyl sulfate in starting materials for API synthesis using derivatization in ionic liquid media and LC–MS

Grinberg, Nelu, Albu, Florin, Fandrick, Keith, Iorgulescu, Elena, Medvedovici, Andrei

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

2013

Language:

english

File:

PDF, 533 KB

english, 2013

5

General and Rapid Pyrimidine Condensation by Addressing the Rate Limiting Aromatization

Fandrick, Daniel R., Reinhardt, Delia, Desrosiers, Jean-Nicolas, Sanyal, Sanjit, Fandrick, Keith R., Ma, Shengli, Grinberg, Nelu, Lee, Heewon, Song, Jinhua J., Senanayake, Chris H.

Journal:

Organic Letters

Year:

2014

Language:

english

File:

PDF, 1.17 MB

english, 2014

6

Case Studies illustrating a science and risk-based approach to ensuring drug quality when using enzymes in the manufacture of Active Pharmaceuticals Ingredients for oral dosage form.

Wells, Andrew S., Wong, John W, Michels, Peter C, Entwistle, david, Fandrick, Keith R., Finch, Gregory L., Goswami, Animesh, Lee, Heewon, mix, stefan, Moody, Thomas S., Pang, Long, sato, robert, Turne

Journal:

Organic Process Research & Development

Year:

2016

Language:

english

File:

PDF, 699 KB

english, 2016

7

On the design of complex drug candidate syntheses in the pharmaceutical industry

Eastgate, Martin D., Schmidt, Michael A., Fandrick, Keith R.

Journal:

Nature Reviews Chemistry

Year:

2017

Language:

english

File:

PDF, 615 KB

english, 2017

8

A Mild Palladium-Catalyzed Suzuki Coupling Reaction of Quinoline Carboxylates with Boronic Acids

Wenjie Li, Joe J. Gao, Yongda Zhang, Wenjun Tang, Heewon Lee, Keith R. Fandrick, Bruce Lu, Chris H. Senanayake

Journal:

Advanced Synthesis & Catalysis

Year:

2011

Language:

english

File:

PDF, 210 KB

english, 2011

9

Enantioselective Friedel—Crafts Alkylations of α,β-Unsaturated 2-Acyl Imidazoles Catalyzed by Bis(oxazolinyl)pyridine—Scandium(III) Triflate Complexes.

David A. Evans, Keith R. Fandrick, Hyun-Ji Song

Journal:

Year:

2005

File:

PDF, 38 KB

2005

10

ChemInform Abstract: Zinc-Catalyzed and -Mediated Propargylations with Propargyl Boronates.

Daniel R. Fandrick, Keith R. Fandrick, Jonathan T. Reeves, Zhulin Tan, Courtney S. Johnson, Heewon Lee, Jinhua J. Song, Nathan K. Yee, Chris H. Senanayake

Journal:

Year:

2010

File:

PDF, 77 KB

2010

11

ChemInform Abstract: Highly Diastereoselective Zinc-Catalyzed Propargylation of tert-Butanesulfinyl Imines.

Daniel R. Fandrick, Courtney S. Johnson, Keith R. Fandrick, Jonathan T. Reeves, Zhulin Tan, Heewon Lee, Jinhua J. Song, Nathan K. Yee, Chris H. Senanayake

Journal:

Year:

2010

File:

PDF, 33 KB

2010

12

ChemInform Abstract: Mild and General Zinc-Alkoxide-Catalyzed Allylations of Ketones with Allyl Pinacol Boronates.

Keith R. Fandrick, Daniel R. Fandrick, Joe J. Gao, Jonathan T. Reeves, Zhulin Tan, Wenjie Li, Jinhua J. Song, Bruce Lu, Nathan K. Yee, Chris H. Senanayake

Journal:

Year:

2010

File:

PDF, 40 KB

2010

13

ChemInform Abstract: A General Copper—BINAP Catalyzed Asymmetric Propargylation of Ketones with Propargyl Boronates.

Keith R. Fandrick, Daniel R. Fandrick, Jonathan T. Reeves, Joe Gao, Shengli Ma, Wenjie Li, Heewon Lee, Nelu Grinberg, Bruce Lu, Chris H. Senanayake

Journal:

Year:

2011

File:

PDF, 37 KB

2011

14

ChemInform Abstract: A Mild Palladium-Catalyzed Suzuki Coupling Reaction of Quinoline Carboxylates with Boronic Acids.

Wenjie Li, Joe J. Gao, Yongda Zhang, Wenjun Tang, Heewon Lee, Keith R. Fandrick, Bruce Lu, Chris H. Senanayake

Journal:

Year:

2011

File:

PDF, 35 KB

2011

15

ChemInform Abstract: Asymmetric Synthesis of Diverse α,α-Diarylmethylamines via Aryl Grignard Additions to Chiral N-2,4,6-Triisopropylbenzenesulfinylimines.

Zhengxu Han, Robert Busch, Keith R. Fandrick, Angelica Meyer, Yibo Xu, Dhileep K. Krishnamurthy, Chris H. Senanayake

Journal:

Year:

2012

File:

PDF, 33 KB

2012

16

ChemInform Abstract: Zinc-Catalyzed Allenylations of Aldehydes and Ketones.

Daniel R. Fandrick, Jaideep Saha, Keith R. Fandrick, Sanjit Sanyal, Junichi Ogikubo, Heewon Lee, Frank Roschangar, Jinhua J. Song, Chris H. Senanayake

Journal:

Year:

2012

File:

PDF, 40 KB

2012

17

2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors

Troy Voelker, Haiji Xia, Keith Fandrick, Robert Johnson, Aaron Janowsky, John R. Cashman

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 1.69 MB

english, 2009

18

Asymmetric synthesis of diverse α,α-diarylmethylamines via aryl Grignard additions to chiral N-2,4,6-triisopropylbenzenesulfinylimines

Zhengxu Han, Robert Busch, Keith R. Fandrick, Angelica Meyer, Yibo Xu, Dhileep K. Krishnamurthy, Chris H. Senanayake

Journal:

Year:

2011

Language:

english

File:

PDF, 1.06 MB

english, 2011

19

Bivalent biogenic amine reuptake inhibitors

Keith Fandrick, Xianqi Feng, Aaron Janowsky, Robert Johnson, John R Cashman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 142 KB

english, 2003

20

Syntheses of 3-carbomethoxy-4-(aryl)piperidines and In vitro and In vivo pharmacological evaluation: identification of inhibitors of the human dopamine transporter

Xianqi Feng, Keith Fandrick, Robert Johnson, Aaron Janowsky, John R Cashman

Journal:

Bioorganic & Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 152 KB

english, 2003

21

Enantioselective Friedel−Crafts Alkylations Catalyzed by Bis(oxazolinyl)pyridine−Scandium(III) Triflate Complexes

Evans, David A., Fandrick, Keith R., Song, Hyun-Ji, Scheidt, Karl A., Xu, Risheng

Journal:

Journal of the American Chemical Society

Year:

2007

Language:

english

File:

PDF, 583 KB

english, 2007

22

Enantioselective Nitrone Cycloadditions of α,β-Unsaturated 2-Acyl Imidazoles Catalyzed by Bis(oxazolinyl)pyridine−Cerium(IV) Triflate Complexes

Song, Hyun-Ji, Fandrick, Keith R., Evans, David A.

Journal:

Organic Letters

Year:

2006

Language:

english

File:

PDF, 187 KB

english, 2006

23

Enantioselective Indole Friedel−Crafts Alkylations Catalyzed by Bis(oxazolinyl)pyridine−Scandium(III) Triflate Complexes

Evans, David A., Scheidt, Karl A., Fandrick, Keith R., Lam, Hon Wai, Wu, Jimmy

Journal:

Journal of the American Chemical Society

Year:

2003

Language:

english

File:

PDF, 97 KB

english, 2003

24

Hydrophosphination of Propargylic Alcohols and Amines with Phosphine Boranes

Busacca, Carl A., Qu, Bo, Farber, Elisa, Haddad, Nizar, Grět, Nicole, Saha, Anjan K., Eriksson, Magnus C., Wu, Jiang-Ping, Fandrick, Keith R., Han, Steve, Grinberg, Nelu, Ma, Shengli, Lee, Heewon, Li,

Journal:

Organic Letters

Year:

2013

Language:

english

File:

PDF, 361 KB

english, 2013

25

[2,3]-Sigmatropic Rearrangements of 2-Phosphineborane 2-Propen-1-ols: Rapid Access to Enantioenriched Diphosphine Monoxide Derivatives

Busacca, Carl A., Qu, Bo, Farber, Elisa, Haddad, Nizar, Grět, Nicole, Saha, Anjan K., Eriksson, Magnus C., Wu, Jiang-Ping, Fandrick, Keith R., Han, Steve, Grinberg, Nelu, Ma, Shengli, Lee, Heewon, Li,

Journal:

Organic Letters

Year:

2013

Language:

english

File:

PDF, 945 KB

english, 2013

26

Copper-Catalyst-Controlled Site-Selective Allenylation of Ketones and Aldehydes with Propargyl Boronates

Fandrick, Keith R., Ogikubo, Junichi, Fandrick, Daniel R., Patel, Nitinchandra D., Saha, Jaideep, Lee, Heewon, Ma, Shengli, Grinberg, Nelu, Busacca, Carl A., Senanayake, Chris H.

Journal:

Organic Letters

Year:

2013

Language:

english

File:

PDF, 987 KB

english, 2013

27

Zinc Catalyzed and Mediated Asymmetric Propargylation of Trifluoromethyl Ketones with a Propargyl Boronate

Fandrick, Daniel R., Reeves, Jonathan T., Bakonyi, Johanna M., Nyalapatla, Prasanth R., Tan, Zhulin, Niemeier, Oliver, Akalay, Deniz, Fandrick, Keith R., Wohlleben, Wolfgang, Ollenberger, Swetlana, So

Journal:

Journal of Organic Chemistry

Year:

2013

Language:

english

File:

PDF, 3.35 MB

english, 2013

28

Carbamoyl Anion Addition to N -Sulfinyl Imines: Highly Diastereoselective Synthesis of α-Amino Amides

Reeves, Jonathan T., Tan, Zhulin, Herbage, Melissa A., Han, Zhengxu S., Marsini, Maurice A., Li, Zhibin, Li, Guisheng, Xu, Yibo, Fandrick, Keith R., Gonnella, Nina C., Campbell, Scot, Ma, Shengli, Gri

Journal:

Journal of the American Chemical Society

Year:

2013

Language:

english

File:

PDF, 845 KB

english, 2013

29

Heart-Cutting Two-Dimensional Ultrahigh-Pressure Liquid Chromatography for Process Development: Asymmetric Reaction Monitoring

Ma, Shengli, Grinberg, Nelu, Haddad, Nizar, Rodriguez, Sonia, Busacca, Carl A., Fandrick, Keith, Lee, Heewon, Song, Jinhua J., Yee, Nathan, Krishnamurthy, Dhileepkumar, Senanayake, Chris H., Wang, Jin

Journal:

Organic Process Research & Development

Year:

2013

Language:

english

File:

PDF, 656 KB

english, 2013

30

Copper Catalyzed Asymmetric Propargylation of Aldehydes

Fandrick, Daniel R., Fandrick, Keith R., Reeves, Jonathan T., Tan, Zhulin, Tang, Wenjun, Capacci, Andrew G., Rodriguez, Sonia, Song, Jinhua J., Lee, Heewon, Yee, Nathan K., Senanayake, Chris H.

Journal:

Journal of the American Chemical Society

Year:

2010

Language:

english

File:

PDF, 222 KB

english, 2010

31

Mild and General Zinc-Alkoxide-Catalyzed Allylations of Ketones with Allyl Pinacol Boronates

Fandrick, Keith R., Fandrick, Daniel R., Gao, Joe J., Reeves, Jonathan T., Tan, Zhulin, Li, Wenjie, Song, Jinhua J., Lu, Bruce, Yee, Nathan K., Senanayake, Chris H.

Journal:

Organic Letters

Year:

2010

Language:

english

File:

PDF, 573 KB

english, 2010

32

Tuning the Peri Effect for Enantioselectivity: Asymmetric Hydrogenation of Unfunctionalized Olefins with the BIPI Ligands

Busacca, Carl A., Qu, Bo, Grět, Nicole, Fandrick, Keith R., Saha, Anjan K., Marsini, Maurice, Reeves, Diana, Haddad, Nizar, Eriksson, Magnus, Wu, Jiang-Ping, Grinberg, Nelu, Lee, Heewon, Li, Zhibin, L

Journal:

Advanced Synthesis & Catalysis

Year:

2013

Language:

english

File:

PDF, 277 KB

english, 2013

33

Catalytic Enantioselective Pyrrole Alkylations of α,β-Unsaturated 2-Acyl Imidazoles

Evans, David A., Fandrick, Keith R.

Journal:

Organic Letters

Year:

2006

Language:

english

File:

PDF, 108 KB

english, 2006

34

Amine-Tunable Ruthenium Catalysts for Asymmetric Reduction of Ketones

Rodríguez, Sonia, Qu, Bo, Fandrick, Keith R., Buono, Frederic, Haddad, Nizar, Xu, Yibo, Herbage, Melissa A., Zeng, Xingzhong, Ma, Shengli, Grinberg, Nelu, Lee, Heewon, Han, Zhengxu S., Yee, Nathan K.,

Journal:

Advanced Synthesis & Catalysis

Year:

2014

Language:

english

File:

PDF, 535 KB

english, 2014

35

A General Copper–BINAP-Catalyzed Asymmetric Propargylation of Ketones with Propargyl Boronates

Fandrick, Keith R., Fandrick, Daniel R., Reeves, Jonathan T., Gao, Joe, Ma, Shengli, Li, Wenjie, Lee, Heewon, Grinberg, Nelu, Lu, Bruce, Senanayake, Chris H.

Journal:

Journal of the American Chemical Society

Year:

2011

Language:

english

File:

PDF, 1.58 MB

english, 2011

36

Zinc-Catalyzed Allenylations of Aldehydes and Ketones

Fandrick, Daniel R., Saha, Jaideep, Fandrick, Keith R., Sanyal, Sanjit, Ogikubo, Junichi, Lee, Heewon, Roschangar, Frank, Song, Jinhua J., Senanayake, Chris H.

Journal:

Organic Letters

Year:

2011

Language:

english

File:

PDF, 903 KB

english, 2011

37

Zinc Catalyzed and Mediated Propargylations with Propargyl Boronates

Fandrick, Daniel R., Fandrick, Keith R., Reeves, Jonathan T., Tan, Zhulin, Johnson, Courtney S., Lee, Heewon, Song, Jinhua J., Yee, Nathan K., Senanayake, Chris H.

Journal:

Organic Letters

Year:

2010

Language:

english

File:

PDF, 459 KB

english, 2010

38

Development of New P -Chiral P ,π-Dihydrobenzooxaphosphole Hybrid Ligands for Asymmetric Catalysis

Sieber, Joshua D., Chennamadhavuni, Divya, Fandrick, Keith R., Qu, Bo, Han, Zhengxu S., Savoie, Jolaine, Ma, Shengli, Samankumara, Lalith P., Grinberg, Nelu, Lee, Heewon, Song, Jinhua J., Senanayake,

Journal:

Organic Letters

Year:

2014

Language:

english

File:

PDF, 1.04 MB

english, 2014

39

Directly Probing the Racemization of Imidazolines by Vibrational Circular Dichroism: Kinetics and Mechanism

Ma, Shengli, Busacca, Carl A., Fandrick, Keith R., Bartholomeyzik, Teresa, Haddad, Nizar, Shen, Sherry, Lee, Heewon, Saha, Anjan, Yee, Nathan, Senanayake, Chris, Grinberg, Nelu

Journal:

Organic Letters

Year:

2010

Language:

english

File:

PDF, 1.17 MB

english, 2010

40

Addressing the Configuration Stability of Lithiated Secondary Benzylic Carbamates for the Development of a Noncryogenic Stereospecific Boronate Rearrangement

Fandrick, Keith R., Patel, Nitinchandra D., Mulder, Jason A., Gao, Joe, Konrad, Michael, Archer, Elizabeth, Buono, Frederic G., Duran, Adil, Schmid, Rolf, Daeubler, Juergen, Fandrick, Daniel R., Ma, S

Journal:

Organic Letters

Year:

2014

Language:

english

File:

PDF, 2.63 MB

english, 2014

41

Inhibition of Human Liver Microsomal ( S )-Nicotine Oxidation by (−)-Menthol and Analogues

MacDougall, James M., Fandrick, Keith, Zhang, Xiaodong, Serafin, Scott V., Cashman, John R.

Journal:

Chemical Research in Toxicology

Year:

2003

Language:

english

File:

PDF, 63 KB

english, 2003

42

Highly Diastereoselective Zinc-Catalyzed Propargylation of tert- Butanesulfinyl Imines

Fandrick, Daniel R., Johnson, Courtney S., Fandrick, Keith R., Reeves, Jonathan T., Tan, Zhulin, Lee, Heewon, Song, Jinhua J., Yee, Nathan K., Senanayake, Chris H.

Journal:

Organic Letters

Year:

2010

Language:

english

File:

PDF, 390 KB

english, 2010

43

Insights into chromatographic enantiomeric separation of allenes on cellulose carbamate stationary phase

Ma, Shengli, Tsui, Hung-Wei, Spinelli, Earl, Busacca, Carl A., Franses, Elias I., Wang, Nien-Hwa Linda, Wu, Ling, Lee, Heewon, Senanayake, Chris, Yee, Nathan, Gonella, Nina, Fandrick, Keith, Grinberg,

Journal:

Journal of Chromatography A

Year:

2014

Language:

english

File:

PDF, 1.94 MB

english, 2014

44

A Mild Dihydrobenzooxaphosphole Oxazoline/Iridium Catalytic System for Asymmetric Hydrogenation of Unfunctionalized Dialins

Qu, Bo, Samankumara, Lalith P., Ma, Shengli, Fandrick, Keith R., Desrosiers, Jean-Nicolas, Rodriguez, Sonia, Li, Zhibin, Haddad, Nizar, Han, Zhengxu S., McKellop, Keith, Pennino, Scott, Grinberg, Nelu

Journal:

Angewandte Chemie International Edition

Year:

2014

Language:

english

File:

PDF, 604 KB

english, 2014

45

Remarkable Enhancement of Enantioselectivity in the Asymmetric Conjugate Addition of Dimethylzinc to ( Z )-Nitroalkenes with a Catalytic [(MeCN) 4 Cu]PF 6 -Hoveyda Ligand Complex

Zeng, Xingzhong, Gao, Joe J., Song, Jinhua J., Ma, Shengli, Desrosiers, Jean-Nicolas, Mulder, Jason A., Rodriguez, Sonia, Herbage, Melissa A., Haddad, Nizar, Qu, Bo, Fandrick, Keith R., Grinberg, Nelu

Journal:

Angewandte Chemie International Edition

Year:

2014

Language:

english

File:

PDF, 421 KB

english, 2014

46

A Mild Dihydrobenzooxaphosphole Oxazoline/Iridium Catalytic System for Asymmetric Hydrogenation of Unfunctionalized Dialins

Qu, Bo, Samankumara, Lalith P., Ma, Shengli, Fandrick, Keith R., Desrosiers, Jean-Nicolas, Rodriguez, Sonia, Li, Zhibin, Haddad, Nizar, Han, Zhengxu S., McKellop, Keith, Pennino, Scott, Grinberg, Nelu

Journal:

Angewandte Chemie

Year:

2014

Language:

english

File:

PDF, 593 KB

english, 2014

47

Study of enantioselectivity on an immobilized amylose carbamate stationary phase under subcritical fluid chromatography

Layton, Catharine, Ma, Shengli, Wu, Ling, Lee, Heewon, Fandrick, Keith, Fandrick, Daniel, Senanyake, Chris, Yee, Nathan, Grinberg, Nelu, Clark, Jody

Journal:

Journal of Separation Science

Year:

2013

Language:

english

File:

PDF, 734 KB

english, 2013

48

Development of an Asymmetric Synthesis of a Chiral Quaternary FLAP Inhibitor

Fandrick, Keith R., Mulder, Jason A., Patel, Nitinchandra D., Gao, Joe, Konrad, Michael, Archer, Elizabeth, Buono, Frederic G., Duran, Adil, Schmid, Rolf, Daeubler, Juergen, Desrosiers, Jean-Nicolas,

Journal:

Journal of Organic Chemistry

Year:

2015

Language:

english

File:

PDF, 1.72 MB

english, 2015

49

Encyclopedia of Reagents for Organic Synthesis || 2,6-Bis[(4 R ,5 R )-4,5-dihydro-4,5-diphenyl-2-oxazoly]pyridine

Fandrick, Keith R.

Year:

2001

Language:

english

File:

PDF, 60 KB

english, 2001

50

Encyclopedia of Reagents for Organic Synthesis || 2,6-Bis[(4 S ,5 R )-4,5-dihydro-4,5-diphenyl-2-oxazolyl]pyridine

Fandrick, Keith R.

Year:

2001

Language:

english

File:

PDF, 61 KB

english, 2001